The Development of a Novel Gadolinium Chelating Agent for MRI Contrast Agents Employing Carbamoylmethyl-Phosphine Oxides (CMPOs)

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

Shannon Biros

Department

Chemistry

Location

Kirkhof Center KC27

Start Date

11-4-2012 9:00 AM

Keywords

Information, Innovation, and Technology

Abstract

Ionized gadolinium (Gd) is a potent contrast agent used in medical resonance imaging (MRI). As gadolinium is a nephrotoxin, chelating agents are needed to prevent toxicity to the patient. Current chelating agents are available; however, they suffer from a lack of water solubility or by having a negative affect on water's relaxivity rates. An ideal chelating agent binds well to Gd while allowing it to simultaneously interact with individual water molecules. Our lab is developing a novel class of chelating agents containing carbamoylmethyl phosphine oxides (CMPO's), which have the potential to be more soluble in water than current commercially available agents while retaining a favorable affect on water relaxivity.

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Apr 11th, 9:00 AM

The Development of a Novel Gadolinium Chelating Agent for MRI Contrast Agents Employing Carbamoylmethyl-Phosphine Oxides (CMPOs)

Kirkhof Center KC27

Ionized gadolinium (Gd) is a potent contrast agent used in medical resonance imaging (MRI). As gadolinium is a nephrotoxin, chelating agents are needed to prevent toxicity to the patient. Current chelating agents are available; however, they suffer from a lack of water solubility or by having a negative affect on water's relaxivity rates. An ideal chelating agent binds well to Gd while allowing it to simultaneously interact with individual water molecules. Our lab is developing a novel class of chelating agents containing carbamoylmethyl phosphine oxides (CMPO's), which have the potential to be more soluble in water than current commercially available agents while retaining a favorable affect on water relaxivity.