Effect of Increased G-Load on Rat Mammary Gland Development

Presentation Type

Poster/Portfolio

Presenter Major(s)

Cell and Molecular Biology

Mentor Information

Osman Patel

Department

Cell and Molecular Biology

Location

Henry Hall Atrium 13

Start Date

11-4-2012 9:00 AM

Keywords

Health, Life Science

Abstract

Mammary gland epithelial differentiation is dependent on an integral cytoskeletal support structure and hormonal direction. The objective of this study was to determine the effects of chronic hypergravity (HG) exposure during pregnancy on abundance of the cellular scaffolding proteins in the rat mammary gland. One group of pregnant rats were exposed to either 2g (HG) or 1g (control) from days 11 to 20 of gestation (G20). Another control (1g) and experimental (2g) groups were investigated from days 11 of pregnancy through days 1 (P1) and 3 (P3) postpartum. On G20, P1 and P3, mammary tissue was collected and processed for immunohistochemical based quantification of proteins (actin, tubulin cytokeratin, vimentin). At G20, and P3 significant (p

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Apr 11th, 9:00 AM

Effect of Increased G-Load on Rat Mammary Gland Development

Henry Hall Atrium 13

Mammary gland epithelial differentiation is dependent on an integral cytoskeletal support structure and hormonal direction. The objective of this study was to determine the effects of chronic hypergravity (HG) exposure during pregnancy on abundance of the cellular scaffolding proteins in the rat mammary gland. One group of pregnant rats were exposed to either 2g (HG) or 1g (control) from days 11 to 20 of gestation (G20). Another control (1g) and experimental (2g) groups were investigated from days 11 of pregnancy through days 1 (P1) and 3 (P3) postpartum. On G20, P1 and P3, mammary tissue was collected and processed for immunohistochemical based quantification of proteins (actin, tubulin cytokeratin, vimentin). At G20, and P3 significant (p