Faster-than-light Advancement into Cerenkov Luminescence Imaging

Presentation Type

Oral and/or Visual Presentation

Mentor Information

Anthony Chang

Department

Van Andel Institute

Location

Kirkhof Center 2259

Start Date

10-4-2013 12:00 AM

End Date

10-4-2013 12:00 AM

Keywords

Life Science, Physical Science

Abstract

Purpose: Cerenkov radiation (CR) is the visible light emission that occurs when a charged particle, such as a ²+ or ²-, exceeds the speed of light in a medium. CR can be detected by an optical imager with appropriate sensitivity. This study is to develop standard protocols for testing the feasibility of optical imagers for Cerenkov Luminescence Imaging (CLI), and then to utilize the protocols to assess if the AMI-1000 is an appropriate device for CLI. Methods: Two positron emitters (18F, 64Cu) were used to investigate the quality of the AMI-1000. Studies included linearity between radiance and radioactivity, spectrum, signal homogeneity across a source of uniform intensity, spatial resolution, and the in vivo and in vitro correlation between CLI and Positron Emission Tomography (PET). Results: A protocol for testing optical imagers for CLI was successfully developed. Our results in each of these areas demonstrate that the AMI-1000 is a viable optical imager for CLI.

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Apr 10th, 12:00 AM Apr 10th, 12:00 AM

Faster-than-light Advancement into Cerenkov Luminescence Imaging

Kirkhof Center 2259

Purpose: Cerenkov radiation (CR) is the visible light emission that occurs when a charged particle, such as a ²+ or ²-, exceeds the speed of light in a medium. CR can be detected by an optical imager with appropriate sensitivity. This study is to develop standard protocols for testing the feasibility of optical imagers for Cerenkov Luminescence Imaging (CLI), and then to utilize the protocols to assess if the AMI-1000 is an appropriate device for CLI. Methods: Two positron emitters (18F, 64Cu) were used to investigate the quality of the AMI-1000. Studies included linearity between radiance and radioactivity, spectrum, signal homogeneity across a source of uniform intensity, spatial resolution, and the in vivo and in vitro correlation between CLI and Positron Emission Tomography (PET). Results: A protocol for testing optical imagers for CLI was successfully developed. Our results in each of these areas demonstrate that the AMI-1000 is a viable optical imager for CLI.