Effect of L-tyrosine Supplementation on the Muscle Metaboreflex Response

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

James Lang

Department

Movement Science

Location

Henry Hall Atrium 52

Start Date

10-4-2013 3:00 PM

End Date

10-4-2013 4:00 PM

Keywords

Health

Abstract

The muscle metaboreflex functions to increase sympathetic activity in response to the generation of vasoactive metabolites from working skeletal muscle. The resulting blood pressure response is dependent on catecholamine synthesis in synaptic nerve terminals. We hypothesize that oral supplementation of L-tyrosine, the primary substrate for catecholamine biosynthesis, will increase or maintain blood pressure response during metaboreflex activation. Subjects will ingest 150mg/kg of tyrosine prior to performing static handgrip exercise for 2 minutes. Before ending exercise, an arm cuff will be inflated to suprasystolic pressure to arrest blood flow to the forearm. Heart rate and blood pressure were measured throughout the procedure. We anticipate that compared to placebo, heart rate and blood pressure will be elevated as a result of tyrosine supplementation. This suggests that tyrosine is limiting the full expression of effector response to sympathetic activation in young adults.

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Apr 10th, 3:00 PM Apr 10th, 4:00 PM

Effect of L-tyrosine Supplementation on the Muscle Metaboreflex Response

Henry Hall Atrium 52

The muscle metaboreflex functions to increase sympathetic activity in response to the generation of vasoactive metabolites from working skeletal muscle. The resulting blood pressure response is dependent on catecholamine synthesis in synaptic nerve terminals. We hypothesize that oral supplementation of L-tyrosine, the primary substrate for catecholamine biosynthesis, will increase or maintain blood pressure response during metaboreflex activation. Subjects will ingest 150mg/kg of tyrosine prior to performing static handgrip exercise for 2 minutes. Before ending exercise, an arm cuff will be inflated to suprasystolic pressure to arrest blood flow to the forearm. Heart rate and blood pressure were measured throughout the procedure. We anticipate that compared to placebo, heart rate and blood pressure will be elevated as a result of tyrosine supplementation. This suggests that tyrosine is limiting the full expression of effector response to sympathetic activation in young adults.