Progress Towards the Synthesis of Novel Urea Derivatives of T1AM

Presentation Type

Poster/Portfolio

Presenter Major(s)

Chemistry

Mentor Information

Matthew Hart

Department

Chemistry

Location

Henry Hall Atrium 85

Start Date

10-4-2013 2:00 PM

End Date

10-4-2013 3:00 PM

Keywords

Information, Innovation, and Technology, Health, Life Science, Physical Science

Abstract

The thyroid hormone (TH) is excreted by the thyroid gland and plays a pivotal role in organism development and metabolism. Recent research has shown that a metabolite of TH, 3-iodothyronamine (T1AM) is able to evoke biochemical responses in mice, such as hypothermia and cardiac fluctuation in opposition to the effects of TH. T1AM is a known agonist of the trace amine associated receptor (TAAR). Chemical alterations of T1AM may be able to augment these effects and may lead to greater understanding of the role of TAAR in thyroid hormone biology. Specifically, this project examines the incorporation of a urea linkage and altering the substitution pattern on one of the rings of T1AM to an ortho arrangment. Product verification will be done using NMR techniques and HPLC analysis. Once completed, these compounds will be evaluated in cell culture assays using a Hithunter cAMP assay. Progress towards this goal is described herein.

This document is currently not available here.

Share

COinS
 
Apr 10th, 2:00 PM Apr 10th, 3:00 PM

Progress Towards the Synthesis of Novel Urea Derivatives of T1AM

Henry Hall Atrium 85

The thyroid hormone (TH) is excreted by the thyroid gland and plays a pivotal role in organism development and metabolism. Recent research has shown that a metabolite of TH, 3-iodothyronamine (T1AM) is able to evoke biochemical responses in mice, such as hypothermia and cardiac fluctuation in opposition to the effects of TH. T1AM is a known agonist of the trace amine associated receptor (TAAR). Chemical alterations of T1AM may be able to augment these effects and may lead to greater understanding of the role of TAAR in thyroid hormone biology. Specifically, this project examines the incorporation of a urea linkage and altering the substitution pattern on one of the rings of T1AM to an ortho arrangment. Product verification will be done using NMR techniques and HPLC analysis. Once completed, these compounds will be evaluated in cell culture assays using a Hithunter cAMP assay. Progress towards this goal is described herein.