Event Title
New Modulators of TAAR1: Meta Linked Ureas
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Matthew Hart
Department
Chemistry
Location
Henry Hall Atrium 49
Start Date
10-4-2013 10:00 AM
End Date
10-4-2013 11:00 AM
Keywords
Health, Life Science, Physical Science
Abstract
A naturally occurring thyroid hormone (TH) metabolite, 3-Iodothyronamine (T1AM), is a fast acting derivative which activates the Trace Amine Associated Receptor (TAAR1). In mice, T1AM exhibits effects opposite of those induced by TH. This presents a novel regulatory mechanism of TH action. Studying this regulatory mechanism may lead to a grater understanding of thyroid hormone biology and has great meedicinal value. Previously in our lab, a urea derivative of T1AM has been shown to significantly activate TAAR1. This urea contains a para linked aromatic system. The development of new T1AM derivatives will give a better understanding of the structure activity relationship of TAAR1 regulation. To this end, this project focuses on the development of the ureas containing a meta linked aromatic system. This required the synthesis of a key meta diamine that is not commercially available. The results of several synthetic routes to this diamine are described herein.
New Modulators of TAAR1: Meta Linked Ureas
Henry Hall Atrium 49
A naturally occurring thyroid hormone (TH) metabolite, 3-Iodothyronamine (T1AM), is a fast acting derivative which activates the Trace Amine Associated Receptor (TAAR1). In mice, T1AM exhibits effects opposite of those induced by TH. This presents a novel regulatory mechanism of TH action. Studying this regulatory mechanism may lead to a grater understanding of thyroid hormone biology and has great meedicinal value. Previously in our lab, a urea derivative of T1AM has been shown to significantly activate TAAR1. This urea contains a para linked aromatic system. The development of new T1AM derivatives will give a better understanding of the structure activity relationship of TAAR1 regulation. To this end, this project focuses on the development of the ureas containing a meta linked aromatic system. This required the synthesis of a key meta diamine that is not commercially available. The results of several synthetic routes to this diamine are described herein.