Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences, Preprofessional Studies, Cell and Molecular Biology, Biology

Mentor Information

Suganthi Sridhar

Department

Biomedical Sciences

Location

Henry Hall Atrium 101

Start Date

10-4-2013 11:00 AM

End Date

10-4-2013 12:00 PM

Keywords

Health, Life Science

Abstract

Telomeres are double stranded repeats of DNA sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Uncontrolled cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. In normal cells, the length of telomeres decrease with each successive cell division. When the length becomes too short the cells cannot divide and become senescent or die. Telomerase is an enzyme which prevents the degradation of telomeres by adding bases to the ends of the telomere. Cancer cells employ this enzyme telomerase to maintain immortality. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study, BIBR1532, a mixed-type competitive inhibitor, and its synthetic analogues were tested for proliferative activity. A total of 6 compounds were identified to be highly active against proliferation. Upon these results, current tests are being performed on the telomerase activity.

This document is currently not available here.

Share

COinS
 
Apr 10th, 11:00 AM Apr 10th, 12:00 PM

Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells

Henry Hall Atrium 101

Telomeres are double stranded repeats of DNA sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Uncontrolled cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. In normal cells, the length of telomeres decrease with each successive cell division. When the length becomes too short the cells cannot divide and become senescent or die. Telomerase is an enzyme which prevents the degradation of telomeres by adding bases to the ends of the telomere. Cancer cells employ this enzyme telomerase to maintain immortality. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study, BIBR1532, a mixed-type competitive inhibitor, and its synthetic analogues were tested for proliferative activity. A total of 6 compounds were identified to be highly active against proliferation. Upon these results, current tests are being performed on the telomerase activity.