Faculty Scholarly Dissemination Grants
Synthesis and Fluorescence Properties of C-6 Modified 2’Deoxynucleosides
Department
Chemistry
College
College of Liberal Arts and Sciences
Date Range
2011-2012
Abstract
The synthesis of C-6 modified 2-deoxyadenosine and 2-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2-deoxyadenosine and 2-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.
Conference Name
242nd National Meeting of the American Chemical Society
Conference Location
Denver, CO
ScholarWorks Citation
Ngassa, Felix; Gabrielli, Alexandra; Wingellar, Maxwell; MacRae, Matt; and Nwokocha, Goodwill, "Synthesis and Fluorescence Properties of C-6 Modified 2’Deoxynucleosides" (2011). Faculty Scholarly Dissemination Grants. 414.
https://scholarworks.gvsu.edu/fsdg/414
