Female Infertility Treatment, Maternal Characteristics, and Adverse Birth Outcomes
Description
PURPOSE: As the popularity of fertility treatment use has risen, the potential health risks of these treatments for both mother and child are not fully known. Our objective was to determine the association between fertility treatments and adverse birth outcomes of intended pregnancies using the Pregnancy Risk Assessment Monitoring System (PRAMS) data. SUBJECTS: Data from 29,917 intended pregnancies, collected from 2009 – 2018 in the United States, were included in our analysis. METHODS AND MATERIALS: PRAMS data consisted of questionnaire and birth certificate data. SAS 9.4 was used for statistical analyses. ANALYSES: Logistic regression was used to determine the odds ratios (OR) and 95% confidence intervals (CIs) of an adverse birth outcome of fertility treatment use. ORs were also calculated to determine the relationship between maternal demographic, health, and lifestyle factors on these outcomes following fertility treatment. RESULTS: Use of any type of fertility treatment for singleton births was significantly associated with higher odds of a cesarean delivery (OR: 1.3, 95% CI: 1.2-1.5), preterm birth (OR: 1.4. 95% CI: 1.2-1.6), and an infant hospital stay over 5 days (OR: 1.3, 95% CI: 1.1-1.6). Black race, age >40 years, pre-pregnancy obesity, tobacco use, high blood pressure, and depression were also associated with increased odds of multiple adverse birth outcomes. CONCLUSIONS: Patients seeking fertility treatment should be appropriately counseled on the risks of adverse health outcomes for themselves and their child, and be given the resources to address lifestyle factors that could affect their risk prior to treatment.
Female Infertility Treatment, Maternal Characteristics, and Adverse Birth Outcomes
PURPOSE: As the popularity of fertility treatment use has risen, the potential health risks of these treatments for both mother and child are not fully known. Our objective was to determine the association between fertility treatments and adverse birth outcomes of intended pregnancies using the Pregnancy Risk Assessment Monitoring System (PRAMS) data. SUBJECTS: Data from 29,917 intended pregnancies, collected from 2009 – 2018 in the United States, were included in our analysis. METHODS AND MATERIALS: PRAMS data consisted of questionnaire and birth certificate data. SAS 9.4 was used for statistical analyses. ANALYSES: Logistic regression was used to determine the odds ratios (OR) and 95% confidence intervals (CIs) of an adverse birth outcome of fertility treatment use. ORs were also calculated to determine the relationship between maternal demographic, health, and lifestyle factors on these outcomes following fertility treatment. RESULTS: Use of any type of fertility treatment for singleton births was significantly associated with higher odds of a cesarean delivery (OR: 1.3, 95% CI: 1.2-1.5), preterm birth (OR: 1.4. 95% CI: 1.2-1.6), and an infant hospital stay over 5 days (OR: 1.3, 95% CI: 1.1-1.6). Black race, age >40 years, pre-pregnancy obesity, tobacco use, high blood pressure, and depression were also associated with increased odds of multiple adverse birth outcomes. CONCLUSIONS: Patients seeking fertility treatment should be appropriately counseled on the risks of adverse health outcomes for themselves and their child, and be given the resources to address lifestyle factors that could affect their risk prior to treatment.