Synthesis and Fluorescence Analysis of C-6 Modified 2'-Deoxynucleosides

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences, Chemistry

Mentor Information

Felix Ngassa, ngassaf@gvsu.edu

Department

Chemistry

Location

Henry Hall Atrium 7

Start Date

13-4-2011 11:00 AM

End Date

13-4-2011 12:00 PM

Keywords

Life Science

Abstract

The synthesis of C-6 modified 2'-deoxyadenosine and 2'-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2'-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2'-deoxyadenosine and 2'-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.

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Apr 13th, 11:00 AM Apr 13th, 12:00 PM

Synthesis and Fluorescence Analysis of C-6 Modified 2'-Deoxynucleosides

Henry Hall Atrium 7

The synthesis of C-6 modified 2'-deoxyadenosine and 2'-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2'-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2'-deoxyadenosine and 2'-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.