Synthesis of TAAR Regulators Utilizing a Novel Urea Linkage

Presentation Type

Poster/Portfolio

Presenter Major(s)

Chemistry, Biomedical Sciences

Mentor Information

Matthew Hart, hartm@gvsu.edu

Department

Chemistry

Location

Kirkhof Center KC58

Start Date

13-4-2011 11:00 AM

End Date

13-4-2011 12:00 PM

Keywords

Health, Illness, and Healing, Physical Science

Abstract

Unfortunately, there is still a worldwide problem dealing with poor thyroid conditions that limit the effectiveness of the organ's ability to maintain homeostasis. The trace amine associated receptors, also referred to as TAAR, are G-protein coupled receptors that bind with a thyroid hormone metabolite in the body producing immediate physiological effects such as decreased heart rate, body temperature, and metabolism. Our lab has been synthesizing novel ligands for TAAR that regulate its activity. Specifically, this presentation covers the creation of urea derivatives based on a potent activator for TAAR. Small molecule regulators could potentially balance the thyroid hormones effect on homeostasis in the body. These compounds will be evaluated in bio-assays to give us more clues about the molecular basis of TAAR activation and may lead to a greater understanding of its role in biology.

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Apr 13th, 11:00 AM Apr 13th, 12:00 PM

Synthesis of TAAR Regulators Utilizing a Novel Urea Linkage

Kirkhof Center KC58

Unfortunately, there is still a worldwide problem dealing with poor thyroid conditions that limit the effectiveness of the organ's ability to maintain homeostasis. The trace amine associated receptors, also referred to as TAAR, are G-protein coupled receptors that bind with a thyroid hormone metabolite in the body producing immediate physiological effects such as decreased heart rate, body temperature, and metabolism. Our lab has been synthesizing novel ligands for TAAR that regulate its activity. Specifically, this presentation covers the creation of urea derivatives based on a potent activator for TAAR. Small molecule regulators could potentially balance the thyroid hormones effect on homeostasis in the body. These compounds will be evaluated in bio-assays to give us more clues about the molecular basis of TAAR activation and may lead to a greater understanding of its role in biology.