Towards the Synthesis of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

Toni Rice, riceto@gvsu.edu

Department

Chemistry

Location

Henry Hall Atrium 78

Start Date

13-4-2011 10:00 AM

End Date

13-4-2011 11:00 AM

Keywords

Life Science

Abstract

Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, located at the end of human chromosomes is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed to increase binding affinity and selectively over duplex DNA. Efforts towards the convergent synthesis of novel, cyclic compounds will be described in this presentation. Intermediate heterocyclic monomeric units were synthesized using a building block approach involving acid chloride-amine coupling reactions. The final cyclization reaction will be attempted via the use of peptide coupling reagents. These coupling reagents will be used in combination with the cation-template effect, to minimize polymerization reactions. WebMO calculations are being performed to help design energetically favorable compounds. The synthetic and computational results obtained to date will be presented.

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Apr 13th, 10:00 AM Apr 13th, 11:00 AM

Towards the Synthesis of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA

Henry Hall Atrium 78

Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, located at the end of human chromosomes is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed to increase binding affinity and selectively over duplex DNA. Efforts towards the convergent synthesis of novel, cyclic compounds will be described in this presentation. Intermediate heterocyclic monomeric units were synthesized using a building block approach involving acid chloride-amine coupling reactions. The final cyclization reaction will be attempted via the use of peptide coupling reagents. These coupling reagents will be used in combination with the cation-template effect, to minimize polymerization reactions. WebMO calculations are being performed to help design energetically favorable compounds. The synthetic and computational results obtained to date will be presented.