GV-1 Chemical Derivatives as Potential New Antibiotics

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biology

Mentor Information

Rod Morgan, morganr@gvsu.edu

Department

Biology

Location

Henry Hall Atrium 54

Start Date

13-4-2011 9:00 AM

End Date

13-4-2011 10:00 AM

Keywords

Health, Illness, and Healing

Abstract

Despite advancements in many areas of human medicine, infectious disease continues to be a leading cause of morbidity and mortality worldwide. Improper and excessive use of antibacterial compounds has led to the rise of resistant species of bacteria like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Enterococci (VRE), and Extreme Drug Resistant Tuberculosis (XDR-TB). We have found a possible alternative that would replace the current ineffective treatment methods – a potentially new class of antibiotics that inhibits Gram-positive bacteria growth. These chemical compounds have shown inhibition against S. aureus and E. faecalis, and so MRSA and VRE strains were then tested. Inhibition by the newly developed compounds was identical to their inhibition levels against non-resistant strains of both species. These carboxylic amide compounds are novel, non-Penicillin based antibiotics, and could be used to treat MRSA and other Gram-positive infections.

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Apr 13th, 9:00 AM Apr 13th, 10:00 AM

GV-1 Chemical Derivatives as Potential New Antibiotics

Henry Hall Atrium 54

Despite advancements in many areas of human medicine, infectious disease continues to be a leading cause of morbidity and mortality worldwide. Improper and excessive use of antibacterial compounds has led to the rise of resistant species of bacteria like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Enterococci (VRE), and Extreme Drug Resistant Tuberculosis (XDR-TB). We have found a possible alternative that would replace the current ineffective treatment methods – a potentially new class of antibiotics that inhibits Gram-positive bacteria growth. These chemical compounds have shown inhibition against S. aureus and E. faecalis, and so MRSA and VRE strains were then tested. Inhibition by the newly developed compounds was identical to their inhibition levels against non-resistant strains of both species. These carboxylic amide compounds are novel, non-Penicillin based antibiotics, and could be used to treat MRSA and other Gram-positive infections.