Event Title
Hyperbaric Oxygen Therapy and Coronary Vascular Reactivity
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biology, Biomedical Sciences, Health Professions, Psychology
Mentor Information
Francis Sylvester, sylvestf@gvsu.edu
Department
Biomedical Sciences
Location
Henry Hall Atrium 15
Start Date
13-4-2011 1:00 PM
End Date
13-4-2011 2:00 PM
Keywords
Health, Illness, and Healing, Life Science
Abstract
Hyperbaric oxygen treatment utilizes increased pressure to deliver more oxygen to the tissues of the body. Currently, it is commonly used to treat carbon monoxide poisoning and accelerate wound healing. This study aims to characterize the changes in coronary vascular reactivity following acute hyperbaric treatment. In order to evaluate the treatment's effectiveness, porcine coronaries will be dissected, exposed to 2.8 atmospheres of hyperbaric oxygen, and then mounted in isolated organ baths coupled to force transducers. Changes in vascular reactivity (i.e. the ability of blood vessels to change diameter as a means of regulating blood flow) will be measured in response to potassium chloride, sodium nitroprusside, prostaglandin F2alpha and acetylcholine. All of these substances are known vasoconstrictors or vasodilators. It is anticipated that the results of this study will provide insight into the effects of hyperbaric treatment on the cardiovascular system.
Hyperbaric Oxygen Therapy and Coronary Vascular Reactivity
Henry Hall Atrium 15
Hyperbaric oxygen treatment utilizes increased pressure to deliver more oxygen to the tissues of the body. Currently, it is commonly used to treat carbon monoxide poisoning and accelerate wound healing. This study aims to characterize the changes in coronary vascular reactivity following acute hyperbaric treatment. In order to evaluate the treatment's effectiveness, porcine coronaries will be dissected, exposed to 2.8 atmospheres of hyperbaric oxygen, and then mounted in isolated organ baths coupled to force transducers. Changes in vascular reactivity (i.e. the ability of blood vessels to change diameter as a means of regulating blood flow) will be measured in response to potassium chloride, sodium nitroprusside, prostaglandin F2alpha and acetylcholine. All of these substances are known vasoconstrictors or vasodilators. It is anticipated that the results of this study will provide insight into the effects of hyperbaric treatment on the cardiovascular system.