Hyperbaric Oxygen Therapy and Coronary Vascular Reactivity

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biology, Biomedical Sciences, Health Professions, Psychology

Mentor Information

Francis Sylvester, sylvestf@gvsu.edu

Department

Biomedical Sciences

Location

Henry Hall Atrium 15

Start Date

13-4-2011 1:00 PM

End Date

13-4-2011 2:00 PM

Keywords

Health, Illness, and Healing, Life Science

Abstract

Hyperbaric oxygen treatment utilizes increased pressure to deliver more oxygen to the tissues of the body. Currently, it is commonly used to treat carbon monoxide poisoning and accelerate wound healing. This study aims to characterize the changes in coronary vascular reactivity following acute hyperbaric treatment. In order to evaluate the treatment's effectiveness, porcine coronaries will be dissected, exposed to 2.8 atmospheres of hyperbaric oxygen, and then mounted in isolated organ baths coupled to force transducers. Changes in vascular reactivity (i.e. the ability of blood vessels to change diameter as a means of regulating blood flow) will be measured in response to potassium chloride, sodium nitroprusside, prostaglandin F2alpha and acetylcholine. All of these substances are known vasoconstrictors or vasodilators. It is anticipated that the results of this study will provide insight into the effects of hyperbaric treatment on the cardiovascular system.

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Apr 13th, 1:00 PM Apr 13th, 2:00 PM

Hyperbaric Oxygen Therapy and Coronary Vascular Reactivity

Henry Hall Atrium 15

Hyperbaric oxygen treatment utilizes increased pressure to deliver more oxygen to the tissues of the body. Currently, it is commonly used to treat carbon monoxide poisoning and accelerate wound healing. This study aims to characterize the changes in coronary vascular reactivity following acute hyperbaric treatment. In order to evaluate the treatment's effectiveness, porcine coronaries will be dissected, exposed to 2.8 atmospheres of hyperbaric oxygen, and then mounted in isolated organ baths coupled to force transducers. Changes in vascular reactivity (i.e. the ability of blood vessels to change diameter as a means of regulating blood flow) will be measured in response to potassium chloride, sodium nitroprusside, prostaglandin F2alpha and acetylcholine. All of these substances are known vasoconstrictors or vasodilators. It is anticipated that the results of this study will provide insight into the effects of hyperbaric treatment on the cardiovascular system.