Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells

Presentation Type

Poster/Portfolio

Presenter Major(s)

Cell and Molecular Biology

Mentor Information

Suganthi Sridhar, sridhars@gvsu.edu

Department

Biomedical Sciences

Location

Kirkhof Center KC 71

Start Date

13-4-2011 10:00 AM

End Date

13-4-2011 11:00 AM

Keywords

Health, Illness, and Healing, Life Science

Abstract

Unlimited cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. Telomeres are double stranded repeats of TTAGG sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Telomerase, the enzyme that adds telomeres and its inhibition has become an attractive target for new cancer therapeutics. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study BIBR1532, a mixed-type competitive inhibitor, and two synthetic analogues (WS6-48, WS4-43A) were tested for anti-proliferative and migratory activity on metastatic prostate cancer cells. Preliminary studies indicate these compounds are highly active against proliferation. Studies are currently underway on their effects on migration and telomerase activity. If these studies show promising results, we will further research the effect that BIBR1532 and its synthetic analogues have on other metastatic cell lines.

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Apr 13th, 10:00 AM Apr 13th, 11:00 AM

Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells

Kirkhof Center KC 71

Unlimited cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. Telomeres are double stranded repeats of TTAGG sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Telomerase, the enzyme that adds telomeres and its inhibition has become an attractive target for new cancer therapeutics. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study BIBR1532, a mixed-type competitive inhibitor, and two synthetic analogues (WS6-48, WS4-43A) were tested for anti-proliferative and migratory activity on metastatic prostate cancer cells. Preliminary studies indicate these compounds are highly active against proliferation. Studies are currently underway on their effects on migration and telomerase activity. If these studies show promising results, we will further research the effect that BIBR1532 and its synthetic analogues have on other metastatic cell lines.