Event Title
Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells
Presentation Type
Poster/Portfolio
Presenter Major(s)
Cell and Molecular Biology
Mentor Information
Suganthi Sridhar, sridhars@gvsu.edu
Department
Biomedical Sciences
Location
Kirkhof Center KC 71
Start Date
13-4-2011 10:00 AM
End Date
13-4-2011 11:00 AM
Keywords
Health, Illness, and Healing, Life Science
Abstract
Unlimited cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. Telomeres are double stranded repeats of TTAGG sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Telomerase, the enzyme that adds telomeres and its inhibition has become an attractive target for new cancer therapeutics. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study BIBR1532, a mixed-type competitive inhibitor, and two synthetic analogues (WS6-48, WS4-43A) were tested for anti-proliferative and migratory activity on metastatic prostate cancer cells. Preliminary studies indicate these compounds are highly active against proliferation. Studies are currently underway on their effects on migration and telomerase activity. If these studies show promising results, we will further research the effect that BIBR1532 and its synthetic analogues have on other metastatic cell lines.
Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells
Kirkhof Center KC 71
Unlimited cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. Telomeres are double stranded repeats of TTAGG sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Telomerase, the enzyme that adds telomeres and its inhibition has become an attractive target for new cancer therapeutics. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study BIBR1532, a mixed-type competitive inhibitor, and two synthetic analogues (WS6-48, WS4-43A) were tested for anti-proliferative and migratory activity on metastatic prostate cancer cells. Preliminary studies indicate these compounds are highly active against proliferation. Studies are currently underway on their effects on migration and telomerase activity. If these studies show promising results, we will further research the effect that BIBR1532 and its synthetic analogues have on other metastatic cell lines.