Modified Chromenes as Precursors to TAAR Regulators
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Matthew Hart
Department
Chemistry
Location
Kirkhof Center KC36
Start Date
11-4-2012 9:00 AM
Keywords
Life Science, Physical Science
Abstract
200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates. Recent discoveries have shown that a compound known as T1AM is capable of affecting some of these physiological conditions. Our approach is to learn more about how T1AM activates its cognate receptor TAAR through the synthesis of novel regulators. These regulators resemble T1AM. For example, the molecular scaffold that is the basis of our target compounds (known as chromenes) is more rigid than T1AM due to the incorporation of a ring. To date, our research has focused on optimizing the reactions that produce this scaffold. The successful production of a panel of these chromenes has set the stage for subsequent reactions that will allow us to generate many T1AM analogues. By understanding the regulation of TAAR we may gain a greater understanding of its role in biology and human physiology.
Modified Chromenes as Precursors to TAAR Regulators
Kirkhof Center KC36
200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates. Recent discoveries have shown that a compound known as T1AM is capable of affecting some of these physiological conditions. Our approach is to learn more about how T1AM activates its cognate receptor TAAR through the synthesis of novel regulators. These regulators resemble T1AM. For example, the molecular scaffold that is the basis of our target compounds (known as chromenes) is more rigid than T1AM due to the incorporation of a ring. To date, our research has focused on optimizing the reactions that produce this scaffold. The successful production of a panel of these chromenes has set the stage for subsequent reactions that will allow us to generate many T1AM analogues. By understanding the regulation of TAAR we may gain a greater understanding of its role in biology and human physiology.