The Synthesis and Testing of GV-2 Chemical Derivatives for Antibacterial Derivatives

Presentation Type

Poster/Portfolio

Presenter Major(s)

Chemistry

Mentor Information

Rod Morgan, Robert Smart

Department

Biology, Chemistry

Location

Henry Hall Atrium 95

Start Date

11-4-2012 9:00 AM

Keywords

Health, Physical Science

Abstract

Infectious disease prevails in being one of the leading health concerns worldwide due to antibiotic resistant organisms and their growing ability to adapt and spread in hospitals. Antibiotic resistant strains of Gram-positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin enterococci (VRE), have been steadily increasing since 1972 because of improper and excessive use of antibiotics, contributing to the ability of the bacteria to adapt to the antibiotic. The research project focused on developing a series of new antimicrobial compounds and testing their activity against antibiotic resistant Gram-positive bacteria. New derivatives of an antibacterial base chemical structure were created by attaching a carbon aliphatic chain of varying lengths onto methylanthrinilic acid (the base structure). These compounds inhibited the growth of S.aureus bacteria with minimum inhibitory concentration (MIC) values ranging from 8-128 ¼g/ml.

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Apr 11th, 9:00 AM

The Synthesis and Testing of GV-2 Chemical Derivatives for Antibacterial Derivatives

Henry Hall Atrium 95

Infectious disease prevails in being one of the leading health concerns worldwide due to antibiotic resistant organisms and their growing ability to adapt and spread in hospitals. Antibiotic resistant strains of Gram-positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin enterococci (VRE), have been steadily increasing since 1972 because of improper and excessive use of antibiotics, contributing to the ability of the bacteria to adapt to the antibiotic. The research project focused on developing a series of new antimicrobial compounds and testing their activity against antibiotic resistant Gram-positive bacteria. New derivatives of an antibacterial base chemical structure were created by attaching a carbon aliphatic chain of varying lengths onto methylanthrinilic acid (the base structure). These compounds inhibited the growth of S.aureus bacteria with minimum inhibitory concentration (MIC) values ranging from 8-128 ¼g/ml.