Event Title
The Synthesis and Testing of GV-2 Chemical Derivatives for Antibacterial Derivatives
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Rod Morgan, Robert Smart
Department
Biology, Chemistry
Location
Henry Hall Atrium 95
Start Date
11-4-2012 9:00 AM
Keywords
Health, Physical Science
Abstract
Infectious disease prevails in being one of the leading health concerns worldwide due to antibiotic resistant organisms and their growing ability to adapt and spread in hospitals. Antibiotic resistant strains of Gram-positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin enterococci (VRE), have been steadily increasing since 1972 because of improper and excessive use of antibiotics, contributing to the ability of the bacteria to adapt to the antibiotic. The research project focused on developing a series of new antimicrobial compounds and testing their activity against antibiotic resistant Gram-positive bacteria. New derivatives of an antibacterial base chemical structure were created by attaching a carbon aliphatic chain of varying lengths onto methylanthrinilic acid (the base structure). These compounds inhibited the growth of S.aureus bacteria with minimum inhibitory concentration (MIC) values ranging from 8-128 ¼g/ml.
The Synthesis and Testing of GV-2 Chemical Derivatives for Antibacterial Derivatives
Henry Hall Atrium 95
Infectious disease prevails in being one of the leading health concerns worldwide due to antibiotic resistant organisms and their growing ability to adapt and spread in hospitals. Antibiotic resistant strains of Gram-positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin enterococci (VRE), have been steadily increasing since 1972 because of improper and excessive use of antibiotics, contributing to the ability of the bacteria to adapt to the antibiotic. The research project focused on developing a series of new antimicrobial compounds and testing their activity against antibiotic resistant Gram-positive bacteria. New derivatives of an antibacterial base chemical structure were created by attaching a carbon aliphatic chain of varying lengths onto methylanthrinilic acid (the base structure). These compounds inhibited the growth of S.aureus bacteria with minimum inhibitory concentration (MIC) values ranging from 8-128 ¼g/ml.