Genetic Variation of Community Associated and Hospital Associated Methicillin Resistant Staphyloccocus aureus (MRSA)
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Doug Graham
Department
Biomedical Sciences
Location
Henry Hall Atrium 6
Start Date
11-4-2012 9:00 AM
Keywords
Life Science
Abstract
There are two types of MRSA, community associated (CA) and hospital associated (HA). The question posed: Is there more genetic variation within the CA-MRSA population than within the HA-MRSA population. Data sets were obtained from the MLST S. aureus database. An advanced search of country and epidemiology yielded; 11 CA-MRSA strains and 14 HA-MRSA strains which were used during this study. Each strain has a specific genetic profile consisting of 7 genes: arc, aroe, glpf, gmk, pta, tpi and yqil. The methods of analysis were variation of the genetic profiles, the mean diversity in entire population, the between group mean distance, and boot-strap phylogenetic tree of entire data set.The results show a significant difference between the groups. Although the sample sizes were small the evidence supports the hypothesis that HA-MRSA has less genetic variation within its population than CA-MRSA; implying that environmental differences may affect the genetic evolution of the two groups.
Genetic Variation of Community Associated and Hospital Associated Methicillin Resistant Staphyloccocus aureus (MRSA)
Henry Hall Atrium 6
There are two types of MRSA, community associated (CA) and hospital associated (HA). The question posed: Is there more genetic variation within the CA-MRSA population than within the HA-MRSA population. Data sets were obtained from the MLST S. aureus database. An advanced search of country and epidemiology yielded; 11 CA-MRSA strains and 14 HA-MRSA strains which were used during this study. Each strain has a specific genetic profile consisting of 7 genes: arc, aroe, glpf, gmk, pta, tpi and yqil. The methods of analysis were variation of the genetic profiles, the mean diversity in entire population, the between group mean distance, and boot-strap phylogenetic tree of entire data set.The results show a significant difference between the groups. Although the sample sizes were small the evidence supports the hypothesis that HA-MRSA has less genetic variation within its population than CA-MRSA; implying that environmental differences may affect the genetic evolution of the two groups.