Genetic Variation of Community Associated and Hospital Associated Methicillin Resistant Staphyloccocus aureus (MRSA)

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

Doug Graham

Department

Biomedical Sciences

Location

Henry Hall Atrium 6

Start Date

11-4-2012 9:00 AM

Keywords

Life Science

Abstract

There are two types of MRSA, community associated (CA) and hospital associated (HA). The question posed: Is there more genetic variation within the CA-MRSA population than within the HA-MRSA population. Data sets were obtained from the MLST S. aureus database. An advanced search of country and epidemiology yielded; 11 CA-MRSA strains and 14 HA-MRSA strains which were used during this study. Each strain has a specific genetic profile consisting of 7 genes: arc, aroe, glpf, gmk, pta, tpi and yqil. The methods of analysis were variation of the genetic profiles, the mean diversity in entire population, the between group mean distance, and boot-strap phylogenetic tree of entire data set.The results show a significant difference between the groups. Although the sample sizes were small the evidence supports the hypothesis that HA-MRSA has less genetic variation within its population than CA-MRSA; implying that environmental differences may affect the genetic evolution of the two groups.

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Apr 11th, 9:00 AM

Genetic Variation of Community Associated and Hospital Associated Methicillin Resistant Staphyloccocus aureus (MRSA)

Henry Hall Atrium 6

There are two types of MRSA, community associated (CA) and hospital associated (HA). The question posed: Is there more genetic variation within the CA-MRSA population than within the HA-MRSA population. Data sets were obtained from the MLST S. aureus database. An advanced search of country and epidemiology yielded; 11 CA-MRSA strains and 14 HA-MRSA strains which were used during this study. Each strain has a specific genetic profile consisting of 7 genes: arc, aroe, glpf, gmk, pta, tpi and yqil. The methods of analysis were variation of the genetic profiles, the mean diversity in entire population, the between group mean distance, and boot-strap phylogenetic tree of entire data set.The results show a significant difference between the groups. Although the sample sizes were small the evidence supports the hypothesis that HA-MRSA has less genetic variation within its population than CA-MRSA; implying that environmental differences may affect the genetic evolution of the two groups.