Investigating the Role of Nrg1p and Tup1p During Candida albicans Chlamydospore Formation

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

Derek Thomas

Department

Biomedical Sciences

Location

Kirkhof Center KC30

Start Date

11-4-2012 9:00 AM

Keywords

Life Science

Abstract

Candidiasis represents the fourth most frequent nosocomial infection both in the US and worldwide. Candida albicans can grow as yeast cells, pseudohyphae or hyphae and produce chlamydospores with its form being dictated by its surrounding conditions. The ability to form hyphal cells has been fundamentally linked to the disease potential of this organism. Nrg1p is a global repressor of the filamentation process of C. albicans and associates with the co-repressor Tup1p during this inhibition of filamentation. Nrg1p has also been shown to play a key role in chlamydospore formation, but the relevance of Tup1p is unknown. In this study we describe differences in the nature of Nrg1p dependent regulation of chlamydospore formation compared to that of filamentation and offer further insights into the functions of Nrg1p in C. albicans. Furthermore we establish that chlamydospore formation is independent of Tup1p.

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Apr 11th, 9:00 AM

Investigating the Role of Nrg1p and Tup1p During Candida albicans Chlamydospore Formation

Kirkhof Center KC30

Candidiasis represents the fourth most frequent nosocomial infection both in the US and worldwide. Candida albicans can grow as yeast cells, pseudohyphae or hyphae and produce chlamydospores with its form being dictated by its surrounding conditions. The ability to form hyphal cells has been fundamentally linked to the disease potential of this organism. Nrg1p is a global repressor of the filamentation process of C. albicans and associates with the co-repressor Tup1p during this inhibition of filamentation. Nrg1p has also been shown to play a key role in chlamydospore formation, but the relevance of Tup1p is unknown. In this study we describe differences in the nature of Nrg1p dependent regulation of chlamydospore formation compared to that of filamentation and offer further insights into the functions of Nrg1p in C. albicans. Furthermore we establish that chlamydospore formation is independent of Tup1p.