The Effects of the Hyperbaric Treatments on Renal Arteries
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Francis Sylvester
Department
Biomedical Sciences
Location
Kirkhof Center KC50
Start Date
11-4-2012 9:00 AM
Keywords
Life Science
Abstract
Renal arteries supply blood to the kidneys and at any moment receive 20-25% of the cardiac output. This high rate of blood flow is critical to renal function and is directed by changes in blood vessel diameter. In this experiment different gases will be used within a hyperbaric chamber to treat arteries obtained from porcine kidneys. Hyperbaric therapy involves breathing or administering gases while in a sealed chamber that has been pressurized to 1.5 times atmospheric pressure. It has been studied and used for a number of health-related applications such as carbon monoxide poisoning, severe anemia, burn injuries, skin grafts and organ storage. Arteries will be stored in a buffer and will be treated in an oxygenated hot water bath. Force transducers will measure active tension within the arteries as phenylephrine and nitroprusside are added. It is hypothesized that treatment with 100% oxygen, 100% nitrogen and room air will alter responses to vasodilators and vasoconstrictors.
The Effects of the Hyperbaric Treatments on Renal Arteries
Kirkhof Center KC50
Renal arteries supply blood to the kidneys and at any moment receive 20-25% of the cardiac output. This high rate of blood flow is critical to renal function and is directed by changes in blood vessel diameter. In this experiment different gases will be used within a hyperbaric chamber to treat arteries obtained from porcine kidneys. Hyperbaric therapy involves breathing or administering gases while in a sealed chamber that has been pressurized to 1.5 times atmospheric pressure. It has been studied and used for a number of health-related applications such as carbon monoxide poisoning, severe anemia, burn injuries, skin grafts and organ storage. Arteries will be stored in a buffer and will be treated in an oxygenated hot water bath. Force transducers will measure active tension within the arteries as phenylephrine and nitroprusside are added. It is hypothesized that treatment with 100% oxygen, 100% nitrogen and room air will alter responses to vasodilators and vasoconstrictors.